Thursday, April 8, 2021

Inhaled vaccines could be better at curbing Covid spread: Experts

Source Website: https://www.tnp.sg/news/singapore/inhaled-vaccines-could-be-better-curbing-covid-spread-experts
By Shabana Begum, The New Paper, 31 March 2021 at 06:00 am


While injectable Covid-19 vaccines have been shown to prevent disease, they have yet to show conclusively that they can reduce transmission.
PHOTO: While injectable Covid-19 vaccines have been shown to prevent disease, they have yet to show conclusively that they can reduce transmission.
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But safety and efficacy of such vaccines must still be proven in clinical trials, say experts.

Covid-19 vaccines that are administered through the nose or mouth could potentially be more effective in blocking the virus at the upper respiratory tract and thus reduce its transmission, said infectious disease experts in Singapore.

But the safety and efficacy of such vaccines still have to be proven in clinical trials, they stressed.


Covid-19 vaccines that are administered through the nose or mouth could potentially be more effective in blocking the virus at the upper respiratory tract and thus reduce its transmission, said infectious disease experts in Singapore.
PHOTO: Covid-19 vaccines that are administered through the nose or mouth could potentially be more effective in blocking the virus at the upper respiratory tract and thus reduce its transmission, said infectious disease experts in Singapore.
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The experts were commenting on Covid-19 vaccines delivered through ways other than injection, after China's drug authority last week approved an inhaled vaccine co-developed by CanSino Biologics for clinical trials.

Inhaled or intranasal vaccines that are sprayed into the nose mimic the way respiratory viruses usually infect a person - by entering the respiratory tract.

These vaccines are expected to induce a strong local immune response in the upper respiratory tract, where the Sars-Cov-2 virus takes hold.


These vaccines are expected to induce a strong local immune response in the upper respiratory tract, where the Sars-Cov-2 virus takes hold.
PHOTO: These vaccines are expected to induce a strong local immune response in the upper respiratory tract, where the Sars-Cov-2 virus takes hold.
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"This local immune response is therefore potentially more effective at blocking the pathogen immediately when the virus is inhaled or comes into contact with the nose," said Associate Professor Sylvie Alonso, co-director of the Infectious Diseases Translational Research Programme at the National University of Singapore's Yong Loo Lin School of Medicine.

There may be a higher chance of reducing human-to-human transmission when the pathogen is effectively neutralised immediately or soon after it starts replicating, she said.

Injectable Covid-19 vaccines that have been approved so far - such as the Pfizer-BioNTech and Moderna shots - have been shown to prevent disease, but have yet to show conclusively that they can reduce transmission.


Injectable Covid-19 vaccines that have been approved so far - such as the Pfizer-BioNTech and Moderna shots - have been shown to prevent disease, but have yet to show conclusively that they can reduce transmission.


Professor Ooi Eng Eong from the emerging infectious diseases programme at Duke-NUS Medical School said the theoretical benefits of intranasal and inhaled Covid-19 vaccines are uncertain without efficacy trials.

These vaccines are in the exploratory stages of testing, noted Prof Ooi, the co-developer of an injectable Covid-19 vaccine that is to undergo phase three trials in the second quarter of this year.

China is not the only place where intranasal Covid-19 vaccines are being studied.


Professor Ooi Eng Eong from the emerging infectious diseases programme at Duke-NUS Medical School said the theoretical benefits of intranasal and inhaled Covid-19 vaccines are uncertain without efficacy trials.
PHOTO: Professor Ooi Eng Eong from the emerging infectious diseases programme at Duke-NUS Medical School said the theoretical benefits of intranasal and inhaled Covid-19 vaccines are uncertain without efficacy trials.
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OXFORD UNIVERSITY
Last Thursday, Britain's Oxford University said it was launching a study of immune responses of a nasal administration of its vaccine developed with AstraZeneca.

In Singapore, home-grown biotech company Esco Aster is working with United States company Vivaldi Biosciences to develop a vaccine that will be delivered as a nasal spray.

Prof Alonso said that as the nasal cavity is close to the brain, developers must ensure that the components of the vaccine cannot reach the brain.


In Singapore, home-grown biotech company Esco Aster is working with United States company Vivaldi Biosciences to develop a vaccine that will be delivered as a nasal spray.
PHOTO: "Two are better than one, because they have a good return for their labor" (Ecclesiastes 4:9) When individuals work together, they can double their strength and get much more done as a team. They also reap the value of having worked in unison, thus creating harmony instead of disorder. Working as one people begins with the efforts of each person, as they work with another person.

"If God is for us, who can be against us?" (Romans 8:31) "Therefore encourage one another and build each other up, just as in fact you are doing." (1 Thessalonians 5:11) "May the God who gives endurance and encouragement give you the same attitude of mind toward each other that Christ Jesus had." (Romans 15:5)

Jesus prayed that we, his followers, would be one, as he and his father are one. Jesus said it is our oneness that will convince the world that God sent him to us and that God loves us, his community here on earth. “I give you a new commandment, that you love one another." (John 13:34)
Picture posted by World Wanderista on 07 August 2016 - Plitvice Lakes NP Croatia
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By Shabana Begum, The New Paper, 31 March 2021 at 06:00 am
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Reference
[1] Shabana Begum, The New Paper, Inhaled vaccines could be better at curbing Covid spread: Experts, posted on 31 March 2021 at 06:00 am, https://www.tnp.sg/news/singapore/inhaled-vaccines-could-be-better-curbing-covid-spread-experts


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